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重组德国小蠊过敏原Bla g2

Recombinant Bla g 2

货号 RP-BG2-1
品牌 INDOOR BIOTECHNOLOGIES 
发货地 上海市
交期 一个月内
规格 250ug
参考价格 0 元
更新时间 2022-05-24 15:29:12

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英文名称
Recombinant Bla g 2

Allergen:	rBla g 2 (Blattella germanica allergen 2 )
Unit:	250µg
Source:	P. pastoris (clone NIG rBla g 2, glycosylation site N93Q mutated)
Mol. Wt:	~37 kD
Purification:	Purified from Pichia pastoris culture supernatant by monoclonal antibody affinity chromatography. Purity by silver stained SDS-PAGE > 95%.
Concentration:	See product insert.
Formulation:	Preservative and carrier-free in phosphate buffered saline, pH 7.4. Filtered through 0.22 µm filter.
Storage:	Store at -20ºC.
Notes:	(1) One glycosylation site was removed in this recombinant leaving two glycosylation sites. The recombinant is glycosylated and has a slightly higher MW than natural. Bla g 2 (36kD). (2) This recombinant form was used to determine the crystal structure of Bla g 2.
Genbank:	U28863 Mutation N93Q, substituted cag (Q) for aac (N)
PDB:	1YG9, 2NR6 (with Fab-7C11), X-ray crystal structures
Product Resources:	Recombinant Bla g 2 Certificate of Analysis
Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.
References:
Arruda LK, Vailes LD, Mann BJ, Shannon J, Fox JW, Vedvick TS, Hayden ML, Chapman MD. Molecular Cloning of a major cockroach (Blatella germanica) allergen, Bla g 2: Sequence homology to the aspartic proteases. J Biol Chem 1995;270:19563-8. Wünschmann S, Gustchina A, Chapman MD, Pomés A. Cockroach allergen Bla g 2: An unusual aspartic proteinase. J Allergy Clin Immunol 2005;116:140-5. Gustchina A, Li M, Wünschmann S, Chapman MD, Pomés A, Wodawer A. Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition. J Mol Biol 2005;348:433-44. Pomés A, Chapman MD, Vailes LD, Blundell TL, Venugopal D. Cockroach allergen Bla g 2: Structure function and implication for allergic sensitization. Amer J Resp Crit Care Med 2002;165:391-7. Li M, Gustchina A, Alexandratos J, Wlodawer A, Wünschmann S, Kepley CL, Chapman MD, Pomés A. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem, 2008;283:22806-22814