【产品名称】
通用名称：阿狄科®非对称二甲基精氨酸检测试剂盒（酶联免疫法）

【预期用途】
适用于人血清、柠檬酸盐和 EDTA 血浆中不对称二甲基-L-精氨酸的定量测定。仅供科研使用。

【包装规格】
96T/盒

【背景知识】
不对称二甲基L-精氨酸是NO合酶的内源性抑制剂。它是在甲基化蛋白质分解过程中形成的，可通过肾脏消除或通过二甲基精氨酸二甲基氨基水解酶代谢。各种细胞类型，包括人类内皮细胞和肾小管细胞，产生和代谢不对称二甲基L-精氨酸。在许多与内皮功能障碍相关的疾病中，不对称二甲基L-精氨酸 的血液水平升高。在患有高胆固醇血症、高血压、动脉硬化、慢性肾功能不全的患者中已经证明 不对称二甲基L-精氨酸浓度升高和慢性心功能不全，并与受限的内皮依赖性血管舒张有关。
近年来，NO对血管张力和结构的调节具有重要的临床意义。据报道，人内皮细胞除NO外还产生不对称二甲基L-精氨酸，这表明内源性NO调节是通过内皮中的不对称二甲基L-精氨酸，因此推测肾功能不全患者高血压、动脉硬化和免疫功能障碍的多发与L-精氨酸/NO代谢受损和不对称二甲基L-精氨酸的蓄积密切相关。迄今为止，导致L-精氨酸-NO代谢变化的机制仅部分阐明。当然，这是一个多因素的现象，i.a.自由基增加，不对称二甲基L-精氨酸积累和NO合酶活性降低。
近年来的前瞻性研究使不对称二甲基L-精氨酸作为一种新的心血管风险标志物或因素变得越来越重要。

适应症：

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