Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

Cell membrane; Lipid-anchor, GPI-anchor.

Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Belongs to the immunoglobulin superfamily. CEA family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Entrez Gene: 4680 Human

Entrez Gene: 100125369 Rat

Omim: 163980 Human

SwissProt: P40199 Human

Unigene: 466814 Human

Unigene: 122781 Rat

CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.