细胞色素C抗体
- bs-0013R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-18 13:58:25
北京博奥森生物技术有限公司
- 英文名称
- Cytochrome C Rabbit pAb
- 别名
- CytC; CYC; CYCS; Cytochrome c somatic; HCS; CYC_HUMAN; Cytochrome-c; MSA06; THC4.
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Binds 1 heme c group covalently per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
The disease is caused by variants affecting the gene represented in this entry
Belongs to the cytochrome c family.
Entrez Gene: 54205 Human
Entrez Gene: 13063 Mouse
Omim: 123970 Human
SwissProt: P99999 Human
SwissProt: P62897 Mouse
Unigene: 437060 Human