淋巴管内皮透明质酸受体抗体
LYVE-1 Rabbit pAb
- bs-20120R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-18 14:09:54
北京博奥森生物技术有限公司
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- 英文名称
- LYVE-1 Rabbit pAb
- 别名
- LYVE1; lymphalic vessel endotheilial hyaluronan receptor 1; CRSBP 1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; HAR; hyaluronic acid receptor; Cell surface retention sequence-binding protein 1; CRSBP-1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1_HUMAN; Lymphatic endothelium specific hyaluronan receptor; LYVE 1; LYVE-1; XLKD1.
产品编号
bs-20120R
产品分类
一抗
产品类型
质检1级
英文名称
LYVE-1 Rabbit pAb
中文名称
淋巴管内皮透明质酸受体抗体
英文别名
LYVE1; lymphalic vessel endotheilial hyaluronan receptor 1; CRSBP 1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; HAR; hyaluronic acid receptor; Cell surface retention sequence-binding protein 1; CRSBP-1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1_HUMAN; Lymphatic endothelium specific hyaluronan receptor; LYVE 1; LYVE-1; XLKD1.
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human LYVE-1
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
32kDa
浓度
1mg/ml
储存液
Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
功能
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
亚基
Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.
亚细胞定位
Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
组织特异性
Restricted to tissues or cell lines expressing erythroid characters.
翻译后修饰
O-glycosylated.
相似性
Contains 1 Link domain.
数据库链接
Entrez Gene: 10894 Human
Entrez Gene: 114332 Mouse
Omim: 605702 Human
SwissProt: Q9Y5Y7 Human
SwissProt: Q8BHC0 Mouse
Unigee: 246769 Human
Unigene: 655332 Human
Unigene: 396078 Mouse
背景资料
The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
