细胞间粘附分子-1（CD54）抗体
ICAM1 Rabbit pAb
- bs-0608R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-18 14:24:04
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- 英文名称
- ICAM1 Rabbit pAb
- 别名
- BB2; CD54 antigen; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor.
产品编号
bs-0608R
产品分类
一抗
产品类型
KO验证抗体、质检1级
英文名称
ICAM1 Rabbit pAb
中文名称
细胞间粘附分子-1（CD54）抗体
英文别名
BB2; CD54 antigen; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor.
交叉反应
Human,Mouse（predicted：Rat）
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CD54
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
56kDa
检测分子量
85-110kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
功能
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
亚基
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
亚细胞定位
Membrane; Single-pass type I membrane protein.
翻译后修饰
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
相似性
Belongs to the immunoglobulin superfamily. ICAM family.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.
数据库链接
Entrez Gene: 3383 Human
Entrez Gene: 15894 Mouse
Omim: 147840 Human
Unigene: 643447 Human
SwissProt: P05362 Human
SwissProt: P13597 Mouse
Unigene: 435508 Mouse
Unigene: 12 Rat
背景资料
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].
