磷酸化蛋白质酪氨酸激酶JAK-1抗体
Phospho-Jak1 (Tyr1034 + Tyr1035) Rabbit pAb
- bs-3238R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-19 15:26:43
北京博奥森生物技术有限公司
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- 英文名称
- Phospho-Jak1 (Tyr1034 + Tyr1035) Rabbit pAb
- 别名
- JAK1 (phospho Y1034 + Y1035); p-JAK1 (phospho Y1034 + Y1035); JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1.
产品编号
bs-3238R
产品分类
一抗
产品类型
磷酸化抗体
英文名称
Phospho-Jak1 (Tyr1034 + Tyr1035) Rabbit pAb
中文名称
磷酸化蛋白质酪氨酸激酶JAK-1抗体
英文别名
JAK1 (phospho Y1034 + Y1035); p-JAK1 (phospho Y1034 + Y1035); JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1.
产品应用
WB, Flow-Cyt, ELISA
交叉反应
Human（predicted：Mouse,Rat,Pig,Cow）
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035:KE(p-Y)(p-Y)TV
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
133kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
功能
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
亚基
Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.
亚细胞定位
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
组织特异性
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.
数据库链接
Entrez Gene: 395681 Chicken
Entrez Gene: 3716 Human
Entrez Gene: 16451 Mouse
Omim: 147795 Human
SwissProt: P23458 Human
SwissProt: P52332 Mouse
Unigene: 207538 Human
Unigene: 289657 Mouse
Unigene: 90191 Rat
背景资料
Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
