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Pertuzumab (PBS)

产品活性：Pertuzumab (PBS) 是一种人源化单克隆抗体，是一种 HER2 二聚抑制剂。可用于转移性 HER2 阳性乳腺癌的研究。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：EGFR

In Vitro: Trastuzumab and Pertuzumab are highly synergistic inhibitors of BT474 breast cancer cell survival. The combination of trastuzumab and Pertuzumab mediates a loss of up to 60% of cells at doses in which individual drugs do not alter cell survival. The combination of trastuzumab and Pertuzumab reduces the percentage of proliferating (S-phase) cells by more than 2-fold. A combination of trastuzumab and Pertuzumab inhibits cell proliferation and survival to a greater degree than does either agent alone.

In Vivo: In Calu-3 NSCLC xenografts, monotherapy with pertuzumab or trastuzumab is able to significantly inhibit tumor growth, with treatment-to-control ratios (TCR) of 0.23 and 0.27, respectively. The combination of trastuzumab and pertuzumab produces a dramatically enhanced antitumor activity compared with single-agent treatments (TCR 0.05, resulting in tumor regression and, in 3 of 10 animals, complete tumor remission). Treatment of KPL-4 breast cancer xenografts with either trastuzumab or pertuzumab inhibits tumor growth with TCRs of 0.67 and 0.65, respectively. Pertuzumab maintains antitumor activity after progression on trastuzumab.

相关产品：Osimertinib  |  Gefitinib  |  Trastuzumab  |  Erlotinib  |  Cetuximab  |  Afatinib  |  AG490  |  Lapatinib  |  Neratinib  |  Tucatinib  |  Genistein  |  AG-1478  |  Mobocertinib  |  Dacomitinib  |  Pertuzumab  |  Trastuzumab deruxtecan (solution)  |  Gefitinib-based PROTAC 3  |  Trastuzumab emtansine  |  Pyrotinib  |  Sapitinib  |  CUDC-101  |  Tuxobertinib  |  Mubritinib  |  NSC 228155  |  BI-4020  |  Pelitinib

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