Catalog Number	PME101052
Package	10 μg ￥600.00 ; 50 μg ￥2350.00 ; 100 μg ￥3380.00
Description	Recombinant human P53 protein with C-terminal human Fc tag
Synonyms	BCC7; BMFS5; LFS1; P53; TRP53
Uniprot ID	P04637
Expression Host	HEK293
Tag	C-Human Fc
Molecular Characterization
Molecular Weight	The protein has a predicted molecular mass of 68.75 kDa after removal of the signal peptide.
Purity	The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Storage	Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage	Research use only
Images
Background	This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

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