Catalog Number	PME100088
Description	Recombinant Human HER3 protein with C-terminal 6×His tag
Synonyms	HER3, ERBB3
Expression Host	HEK293
Tag	C-6×His tag
Molecular Weight	The protein has a predicted molecular mass of 69.39 kDa after removal of the signal peptide.The apparent molecular mass of HER3-His is approximately 100-130 kDa due to glycosylation
Purity	The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining
Buffer	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization
Background	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized

Molecular Characterization


Figure 1. Human HER3 Protein, His Tag on SDS-PAGE under reducing condition.

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