产品编号: KMP2307
产品名称: Human CD226 Protein, Fc Tag
中文名称: 人CD226重组蛋白
中文全称: 人白细胞分化抗原重组蛋白
关键词: 白细胞分化抗原, CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, DNAM1, Human CD226 Protein, Fc Tag, Recombinant Protein, KMP2307

物种: Human
宿主: HEK293 Cells
规格: 50ug, 100ug, 200ug
纯化方式: Affinity purification
纯度: >95% as determined by SDS-PAGE
内毒素水平: <1.0 EU/ug determined by the LAL method
缓冲体系: PBS, pH7.4
Uniprot: Q15762
SDS-PAGE: KMP2307 SDS-PAGE image1.png
功能: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704).
Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
产品背景: Human DNAX accessory molecule 1(DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain(ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, dendritic cell maturation, megakaryocyte and activated platelet adhesion to vascular endothelial cells, and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium, interactions mediated by DNAM-1, enable the metastasis of tumor cells to the lung.
保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明: This product is for research use only.
官网链接: https://www.kmdbioscience.cn/
参考文献: 1.J. Exp. Med. 213:167-176 (2016) 2.Immunity 4:573-581 (1996)